Epidermal Growth Factor Receptor Blockade with C 225 Modulates Proliferation , Apoptosis , and Radiosensitivity in Squamous Cell Carcinomas of the Head and Neck 1

@inproceedings{Huang1999EpidermalGF,
  title={Epidermal Growth Factor Receptor Blockade with C 225 Modulates Proliferation , Apoptosis , and Radiosensitivity in Squamous Cell Carcinomas of the Head and Neck 1},
  author={S M Huang and Jonathan M. Bock and Paul M. Harari},
  year={1999}
}
We examined effects of the anti-epidermal growth factor receptor monoclonal antibody C225 on proliferation, cell cycle phase distribution, apoptosis, and radiosensitivity in squamous cell carcinoma (SCC) cell lines derived from head and neck cancer patients. Exposure to C225 in culture inhibits SCC proliferation in a time-dependent manner, and the degree of growth inhibition, compared to controls, ranges from 20 to 75%. Flow cytometry analysis demonstrates that C225 treatment induces… CONTINUE READING
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