Epidermal Growth Factor Protects the Apical Junctional Complexes from Hydrogen peroxide in Bile Duct Epithelium

@inproceedings{Guntaka2011EpidermalGF,
  title={Epidermal Growth Factor Protects the Apical Junctional Complexes from Hydrogen peroxide in Bile Duct Epithelium},
  author={Srikar R. Guntaka and Geetha Samak and Ankur Seth and Nicholas F. LaRusso and RadhaKrishna Rao},
  booktitle={Laboratory Investigation},
  year={2011}
}
The tight junctions of bile duct epithelium form a barrier between the toxic bile and liver parenchyma. Disruption of tight junctions appears to have a crucial role in the pathogenesis of various liver diseases. In this study, we investigated the disruptive effect of hydrogen peroxide and the protective effect of epidermal growth factor (EGF) on the tight junctions and adherens junctions in the bile duct epithelium. Oxidative stress in NRC-1 and Mz-ChA-1 cell monolayers was induced by… CONTINUE READING
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