Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection.

@article{Tripp2003EpidermalCI,
  title={Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection.},
  author={Catherine S. Tripp and Eric A. G. Blomme and Kevin S. Chinn and Medora M. Hardy and P T Lacelle and Alice P. Pentland},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 4},
  pages={853-61}
}
The cyclooxygenase isoforms, COX-1 and COX-2, are involved in the biosynthesis of prostaglandin E2, a major prostaglandin involved in epidermal homeostasis and repair. Cancer originating in the epidermis can develop when keratinocyte proliferation and apoptosis become dysregulated, resulting in sustained epidermal hyperplasia. COX-2 inhibitors, which demonstrate significant in vivo selectivity relative to COX-1, suppress both ultraviolet-induced epidermal tumor development and progression… CONTINUE READING

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The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
COX-2 inhibitors , which demonstrate significant in vivo selectivity relative to COX-1 , suppress both ultraviolet - induced epidermal tumor development and progression , suggesting that prostaglandin regulation of keratinocyte biology is involved in the pathogenesis of epidermal neoplasia .
The cyclooxygenase isoforms , COX-1 and COX-2 , are involved in the biosynthesis of prostaglandin E2 , a major prostaglandin involved in epidermal homeostasis and repair .
ProstaglandinsChemical structure ofDinoprostone
The cyclooxygenase isoforms , COX-1 and COX-2 , are involved in the biosynthesis of prostaglandin E2 , a major prostaglandin involved in epidermal homeostasis and repair .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
The role of COX-2 was further evaluated using a selective COX-2 inhibitor , SC-791 , as well as the traditional nonsteroidal COX inhibitor , indomethacin .
COX-2 inhibitors , which demonstrate significant in vivo selectivity relative to COX-1 , suppress both ultraviolet - induced epidermal tumor development and progression , suggesting that prostaglandin regulation of keratinocyte biology is involved in the pathogenesis of epidermal neoplasia .
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