Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

Abstract

Sustained epidermal Wnt/β-catenin signalling expands the stem cell compartment and induces ectopic hair follicles (EFs). This is accompanied by extensive fibroblast proliferation and extracellular matrix (ECM) remodelling in the underlying dermis. Here we show that epidermal Hedgehog (Hh) and Transforming growth factor-beta (TGF-β) signalling mediate the… (More)
DOI: 10.1038/ncomms10537

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