Epidemiology of vancomycin-resistant enterococci with reduced susceptibility to daptomycin.


A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.

DOI: 10.1086/668438

Cite this paper

@article{Judge2012EpidemiologyOV, title={Epidemiology of vancomycin-resistant enterococci with reduced susceptibility to daptomycin.}, author={Theresa Judge and Jason M. Pogue and Dror Marchaim and Kevin King-man Ho and Srinivasa Kamatam and Shakila Parveen and Namita Tiwari and Priyanka Nanjireddy and Suchitha Bheemreddy and Caitlin Biedron and Sagar Mallikethi Lepakshi Reddy and Vijaykumar Khammam and Indu K Chalana and Rajachendra Shekher Tumma and Vicki L Collins and Adnan Yousuf and Paul R. Lephart and Emily Toth Martin and Michael J Rybak and Keith S. Kaye and Kayoko Hayakawa}, journal={Infection control and hospital epidemiology}, year={2012}, volume={33 12}, pages={1250-4} }