Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden

@article{Danchenko2006EpidemiologyOS,
  title={Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden},
  author={Natalya Danchenko and Jessie A. Satia and Mary S. Anthony},
  journal={Lupus},
  year={2006},
  volume={15},
  pages={308 - 318}
}
Systemic lupus erythematosus (SLE) is a disease of multifactorial etiology. Quantifying the burden of SLE across different countries can clarify the role of genetic, environmental and other causative factors in the natural history of the disease, and to understand its clinical and societal consequences. The aim of this study is to summarize data on SLE incidence and prevalence in the USA, Europe, Asia, and Australia. An extensive review of electronic resources (PubMed and MedLine) and medical… 

Figures and Tables from this paper

Clinical characteristics of patients with systemic lupus erythematosus in Nairobi, Kenya

TLDR
In Nairobi, SLE is a multisystem disorder affecting predominantly young females and a higher prevalence of haematological and lower rate of renal disease as compared to other studies done in black Africans.

Systemic lupus erythematosus in Asia: is it more common and more severe?

TLDR
SLE is generally not more prevalent in Asian than Caucasian populations, although it is more prevalent among Asian migrants, and SLE has more severe clinical manifestations among Asians compared with Caucasians.

Editorial: Updates in US Systemic Lupus Erythematosus Epidemiology: Tales of Two Cities

TLDR
Two reports in this issue of Arthritis & Rheumatology describe collaborative studies offering muchneeded updates on the epidemiology of SLE in the US, derived from two comparable urban populations, Atlanta and Detroit and their surrounding areas.

Introductory Chapter: Systemic Lupus Erythematosus - Different Predisposing Factors

TLDR
It is found that autoreactive T cells hold responsible for the activation of B cells that might be stimulated to produce antibodies by high levels of cytokines (pro-inflammatory) such as interleukin 10 and IL-12 causing B cell impairment in different SLE patients.

An Overvriew of Systemic Lupus Erythematosus (SLE) Screening, Prevalence and Incidence

TLDR
There was a wide variation in both the incidence and prevalence of SLE in different countries, and gender showed significant differences with females have much higher rates compared to males.

Role of MHC-Linked Susceptibility Genes in the Pathogenesis of Human and Murine Lupus

TLDR
The role of MHC-linked susceptibility genes in the pathogenesis of systemic lupus erythematosus is reviewed, notably with the publication of genome-wide association studies in humans and the identification of susceptibility genes and loci in mice.

The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus

TLDR
Race/ethnicity remains a key determinant of poor outcome, such as end-stage renal failure and mortality, in SLE, and community measures to expedite diagnosis through increased awareness in at-risk racial/ethnic populations and ethnically personalized treatment algorithms may help in future to improve long-term outcomes inSLE.

A Contemporary Update on the Diagnosis of Systemic Lupus Erythematosus

TLDR
This review provides new insight into the diagnosis of SLE by summarizing recent advances in epidemiology, etiology, classification criteria, clinical manifestations, and study of autoantibodies.

Variations in the epidemiology of systemic lupus erythematosus in southern Sweden

TLDR
The incidence rate of SLE in younger females remained stable from 1981 to 2006, however, in middle-aged women the incidence was substantially reduced in the latter half of the study period.
...

References

SHOWING 1-10 OF 47 REFERENCES

The epidemiology of systemic lupus erythematosus

TLDR
The most important data regarding the incidence and prevalence of systemic lupus erythematosus in the general population, the epidemiologic information on the patterns of disease expression in specific subsets and the studies on mortality in SLE are reviewed.

Systemic lupus erythematosus

TLDR
Systemic lupus erythematosus is a relapsing and remitting disease, and treatment aims are threefold: managing acute periods of potentially life-threatening ill health, minimizing the risk of flares during periods of relative stability, and controlling the less life- threatening, but often incapacitating day to day symptoms.

Epidemiology of systemic lupus erythematosus in a northern Spanish population: gender and age influence on immunological features

TLDR
E epidemiological and immunological features of systemic lupus erythematosus (SLE) in a Caucasian population from the north of Spain (Asturias) are researched, observing a trend towards a higher presence of autoantibodies related to an early disease onset.

The epidemiology of systemic lupus erythematosus.

Systemic lupus erythematosus in North American Indians: a population based study.

TLDR
The prevalence of SLE was increased 2-fold in the NAI population and ethnicity increased the likelihood of death more than 4-fold, and therapy for NAI was compared with the results in Caucasians.

Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis.

TLDR
The incidence of SLE in Sweden was notably constant during the 11 years 1981-91 and only late mortality (> 10 years disease duration) exceeded that in an age and sex matched control population.

[Systemic lupus erythematosus in Martinique: an epidemiologic study].

TLDR
The high incidence of SLE in Martinique and the immunological characteristics of patients were found to be similar to those described in other populations of African descent.

Systemic lupus erythematosus in Australian aborigines: high prevalence, morbidity and mortality.

TLDR
There is a high prevalence of SLE in NT Aborigines and the true prevalence is likely to be even higher, although morbidity and mortality may have been overestimated for the same reason.