Epidemiology of septo-optic dysplasia with focus on prevalence and maternal age - A EUROCAT study.

  title={Epidemiology of septo-optic dysplasia with focus on prevalence and maternal age - A EUROCAT study.},
  author={Ester Garne and Anke Rissmann and Marie Claude Addor and Ingeborg Bari{\vs}i{\'c} and Jorieke E. H. Bergman and Paula Braz and Clara Cavero-Carbonell and Elizabeth S. Draper and Miriam Gatt and Martin Haeusler and Kari Klungs{\o}yr and Jennifer J Kurinczuk and Nathalie Lelong and Karen Luyt and Catherine Lynch and Mary T. O’Mahony and Olatz Mokoroa and V. J. Nelen and Amanda Julie Neville and Anna Pierini and Hanitra Randrianaivo and Judith Rankin and Florence Rouget and Bruno Schaub and David Tucker and Christine Verellen-Dumoulin and Diana Wellesley and Awi Wiesel and Nataliia Zymak-Zakutnia and Monica Lanzoni and Joan K. Morris},
  journal={European journal of medical genetics},
  volume={61 9},

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Hypothesis: septo-optic dysplasia is a vascular disruption sequence.

  • M. Lubinsky
  • Medicine
    American journal of medical genetics
  • 1997
Septo-optic dysplasia, a variable combination of absence of the septum pellucidum, optic nerve hypoplasia, and pituitary abnormalities, makes little embryologic sense, so vascular vulnerabilities of components, anatomical overlap with findings of hydranencephaly and porencephaly, and a decreased maternal age effect similar to that of other abnormalities with presumed vascular origins, suggest a vascular disruption sequence.