Epidemiology of leukemia in children with Down syndrome.

  title={Epidemiology of leukemia in children with Down syndrome.},
  author={Julie A. Ross and Logan G. Spector and Leslie L. Robison and Andrew F. Olshan},
  journal={Pediatric blood & cancer},
  volume={44 1},
Studies suggest nearly a 20-fold increased risk of leukemia in individuals with Down syndrome. Most of this increased risk appears in the first few decades of life, with the highest incidence in children less than 5 years of age. It is unknown why children with Down syndrome are at such an increased risk of leukemia. With respect to environmental exposures, it will be important to investigate risk factors associated with childhood leukemia in general (including diagnostic x-rays, pesticides… CONTINUE READING
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