Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges.

@article{Shallis2019EpidemiologyOA,
  title={Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges.},
  author={Rory Michael Shallis and Rong Wang and Amy J. Davidoff and Xiaomei Ma and Amer M. Zeidan},
  journal={Blood reviews},
  year={2019},
  volume={36},
  pages={
          70-87
        }
}
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215 Citations
Highly Influential Citations
2
Background Citations
72
Methods Citations
2
Results Citations
3

215 Citations

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Citation Type

Exciting times ahead for older patients with acute myeloid leukemia: azacitidine and venetoclax followed by allogeneic hematopoietic cell transplantation
TLDR
Venetoclax-based combinations are rendered the new standard of care in older adults with newly diagnosed AML, despite the increased risk of myelosuppression and febrile neutropenia, and relapses still occur with more resistant clones.
Deciphering the Therapeutic Resistance in Acute Myeloid Leukemia
TLDR
The latest insights in AML biology concerning refractoriness to therapies with a specific focus on cytarabine and daunorubicin which still represent milestones agents for inducing therapeutic response and disease eradication are reviewed.
Therapy-Related Acute Myeloid Leukemia Diagnosed at Postmortem in a Long-term Survivor of Advanced Hepatocellular Carcinoma
TLDR
The microscopic examination of the autopsy samples revealed extensive extramedullary infiltration of leukemia, which was confirmed as an AML by a series of ancillary immunohistochemical staining, which illustrates the importance of careful hematologic observation in cancer survivors.
Is outcome of older people with acute myeloid leukemia improving with new therapeutic approaches and stem cell transplantation?
TLDR
Appropriate selection among different options on the basis of clinical fitness and molecular findings at diagnosis as well as at relapse would result in improvement of therapeutic results, sparing unnecessary toxicity and optimizing health systems resources.
Maintenance therapies in acute myeloid leukemia: the renaissance of an old therapeutic concept
TLDR
Maintenance therapies following intensive chemotherapy or allo-HCT offer a new therapeutic paradigm for an increasing number of AML patients and have been shown to result in an OS benefit in selected patients.
The golden age for patients in their golden years: The progressive upheaval of age and the treatment of newly-diagnosed acute myeloid leukemia.
The Current Understanding of and Treatment Paradigm for Newly-Diagnosed TP53-Mutated Acute Myeloid Leukemia
TLDR
This review discusses the considerations behind the study of concurrent cytogenetic risk and predicted TP53 allelic state, measurable residual disease status and the impact of conditioning intensity for patients proceeding to allogeneic hematopoietic stem cell transplantation, and offers the current treatment approach to TP53-mutated AML.
The clinical profile, management, and outcome of febrile neutropenia in acute myeloid leukemia from resource constraint settings
TLDR
The number of days required to develop febrile neutropenia was inversely associated with overall survival (OS); however, when compared, there was no statistically significant difference in OS between patients developing fever on day-10 and day-25, emphasizing the importance of preventive measures against infections.
Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved.
Molecular Monitoring in Acute Myeloid Leukemia Patients Undergoing Matched Unrelated Donor: Hematopoietic Stem Cell Transplantation
TLDR
Analysis of data of AML patients who underwent matched unrelated donor (MUD) HSCT since the introduction of this procedure in the Republic of North Macedonia suggests regular MRD monitoring helps predict impending relapse and direct future treatment strategies.
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