Epidemiology of Parkinson's disease

@article{Lau2006EpidemiologyOP,
  title={Epidemiology of Parkinson's disease},
  author={L. D. Lau and M. Breteler},
  journal={The Lancet Neurology},
  year={2006},
  volume={5},
  pages={525-535}
}
The causes of Parkinson's disease (PD), the second most common neurodegenerative disorder, are still largely unknown. Current thinking is that major gene mutations cause only a small proportion of all cases and that in most cases, non-genetic factors play a part, probably in interaction with susceptibility genes. Numerous epidemiological studies have been done to identify such non-genetic risk factors, but most were small and methodologically limited. Larger, well-designed prospective cohort… Expand
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References

SHOWING 1-10 OF 116 REFERENCES
To die or grow: Parkinson's disease and cancer
TLDR
When considering the normal function of these PD-linked genes in the periphery and their potential role in cancer, further emphasis might be placed on protein handling relating to cell-cycle control in the etiology of PD. Expand
Occupational and environmental risk factors for Parkinson's disease.
TLDR
This paper provides an overview of major occupational and environmental factors that have been associated with the development of PD and tries to assess current thinking about these factors and their possible mechanisms of operation. Expand
Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
TLDR
The results of seven population-based studies were examined separately and pooled to obtain age- and sex-specific estimates of the prevalence of PD and found no sex differences in prevalence. Expand
Genes and parkinsonism
TLDR
The molecular genetics of Parkinson's disease as currently understood is described to help explain the pathways that underlie neurodegeneration. Expand
Dementia associated with Parkinson's disease
  • M. Emre
  • Medicine
  • The Lancet Neurology
  • 2003
TLDR
The main pathology seems to be Lewy-body-type degeneration with associated cellular and synaptic loss in cortical and limbic structures and Alzheimer's disease-type pathology is commonly associated with dementia but less predictive. Expand
Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom
  • P. Hobson, J. Meara
  • Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2004
TLDR
Dementia was found to be a significant predictor for institutional placement in the PD group, and this finding has significant implications for successful clinical management of this condition. Expand
Prevalence of Parkinson's disease and other types of parkinsonism
TLDR
The prevalence figures for Parkinson's disease and other types of parkinsonism in a Sicilian population are higher than those previously reported in Italy or elsewhere, which may be due, in part, to more complete case-ascertainment. Expand
PINK, PANK, or PARK? A clinicians' guide to familial parkinsonism
TLDR
The recent developments in the genetics of Parkinson's disease that have shaped the current understanding and management of this disease and other parkinsonian disorders are detailed. Expand
Alzheimer's disease and Parkinson's disease.
TLDR
The genetics of these familial forms of Alzheimer's and Parkinson's disease are examined to improve understanding of the pathobiology of the more common, sporadic forms of the diseases. Expand
The frequency and associated risk factors for dementia in patients with Parkinson's disease.
TLDR
Patients with PD, especially those with severe extrapyramidal signs, have almost twice the risk for the development of dementia than do community-dwelling control subjects. Expand
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