Epidemiology of Kaposi's sarcoma‐associated herpesvirus in Asia: Challenges and opportunities

  title={Epidemiology of Kaposi's sarcoma‐associated herpesvirus in Asia: Challenges and opportunities},
  author={Tiejun Zhang and Linding Wang},
  journal={Journal of Medical Virology},
Kaposi's sarcoma—associated herpes virus (KSHV) also referred to as human herpesvirus‐8 (HHV‐8), is a gamma herpes virus and recently discovered human virus. Since its discovery, a myriad of studies has been conducted to explore its pathogenesis mechanisms. However, despite our consistently increasing understanding of KSHV biology and its clinical manifestations, only little progress has been made in understanding of its epidemiology characteristics which in turn hampered the management of KSHV… 
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Epidemiology and Transmission of Kaposi’s Sarcoma-Associated Herpesvirus
This review summarizes the current knowledge pertaining to Kaposi sarcoma-associated herpesvirus (KSHV) epidemiology and transmission and indicates that salivary transmission is the main route of transmission, especially in children residing in endemic areas.
Kshv is a gammaherpesvirus, which like its relatives establishes a latent form of infection that appears to be a prerequisite for expression of a disease phenotype, and the relevant disease states and the basic virology are discussed.
The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
Kaposi sarcoma-associated herpesvirus-associated malignancies: epidemiology, pathogenesis, and advances in treatment.
The understanding of viral and immune mechanisms of oncogenesis continues to expand and lead to improved molecular diagnostics, as well as novel therapeutic strategies that employ immune modulatory agents, manipulations of the tumor microenvironment, virus-activated cytotoxic therapy, or agents that target interactions between specific virus-host cell signaling pathways.
A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma
It is suggested that the presence of novel, herpes virus DNA sequences in more than 90% of AIDS Kaposi lesions (AKS) would strongly suggest a specific, aetiopathological involvement of this putative new herpes virus in the pathogenesis of Kaposi's sarcoma, rather than a contamination of yet another opportunistic virus in immunosuppressed AIDS patients.
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Investigation of molecular virological features of KSHV strains from Xinjiang reveals the general consistency of the biological and pathological properties of local KS with others, but characteristics associated with unique ethnicity evolution still remain.
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