Epidemiology and pathogenesis of influenza.

  title={Epidemiology and pathogenesis of influenza.},
  author={Maria Zambon},
  journal={The Journal of antimicrobial chemotherapy},
  volume={44 Suppl B},
  • M. Zambon
  • Published 1 November 1999
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
Influenza A, B and C all have a segmented genome, although only certain influenza A subtypes and influenza B cause severe disease in humans. The two major proteins of influenza are the surface glycoproteins-haemagglutinin (HA) and neuraminidase (NA). HA is the major antigen for neutralizing antibodies and is involved in the binding of virus particles to receptors on host cells. Pandemics are a result of novel virus subtypes of influenza A, created by reassortment of the segmented genome… 

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