Epidemiology and genetics of alopecia areata.

  title={Epidemiology and genetics of alopecia areata.},
  author={A J Mcdonagh and Rachid Tazi-Ahnini},
  journal={Clinical and experimental dermatology},
  volume={27 5},
The frequency of alopecia areata and observed patterns of heritability are in keeping with a polygenic inheritance model but the genetics of alopecia areata is still poorly understood. The role of environmental factors in triggering disease initiation or exacerbation remains almost entirely speculative. Using the candidate gene approach, three susceptibility/severity factors have been identified. HLA alleles were the first to show a strong association with alopecia areata and some DQB and DR… CONTINUE READING

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