Epidemiology, aetiology, risk of rupture and treatment of abdominal aortic aneurysms: does sex matter?

Abstract

OBJECTIVES To unravel the extent to which gender plays a role in the epidemiology, aetiology, risk of rupture and treatment of abdominal aortic aneurysms (AAAs) and to give an overview of these factors. DESIGN, MATERIALS AND METHODS A literature review was performed in the Medline database and Cochrane Library for gender-specific articles on epidemiology, aetiology, risk of rupture and treatment of AAAs. RESULTS Our literature review suggests that the prevalence of AAA in women is underestimated. Regarding aetiology, an oestrogen-mediated reduction in macrophage MMP-9 production seems to be an important mechanism causing gender-related differences in AAA development. We found consensus in the literature that women run a greater risk of rupture compared to men under the current management rules for AAAs. Their treatment mortality also seems to be higher for both elective and ruptured repair. CONCLUSIONS Gender-specific guidelines should be put into place for the management of AAAs and awareness for this disease should be increased, both in women themselves and in their doctors.

DOI: 10.1016/j.ejvs.2009.05.004
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@article{Grootenboer2009EpidemiologyAR, title={Epidemiology, aetiology, risk of rupture and treatment of abdominal aortic aneurysms: does sex matter?}, author={Nathalie Grootenboer and Johanna L. Bosch and Johanna M. Hendriks and M. R. H. M. van Sambeek}, journal={European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery}, year={2009}, volume={38 3}, pages={278-84} }