Epidemiological studies of large resistance plasmids in Haemophilus.

  title={Epidemiological studies of large resistance plasmids in Haemophilus.},
  author={Nicholas I. Leaves and Ioanna Dimopoulou and Ian S. Hayes and S. R. Kerridge and Tim Falla and Ousman Secka and Richard A. Adegbola and Mary P. E. Slack and Tim E. A. Peto and Derrick W. Crook},
  journal={The Journal of antimicrobial chemotherapy},
  volume={45 5},
The distribution of large conjugative Haemophilus influenzae plasmids in the nasopharyngeal haemophili of a group of people and in a large collection of 541 H. influenzae type b (Hib) isolates was studied. A newly developed PCR-based assay was used to detect the plasmids. The target sequences were chosen from sequence analysis of part of p1056, a large multiresistance plasmid isolated from a clinical Hib isolate, 1056. Fifty-nine per cent of people were found to carry beta-lactamase-positive… CONTINUE READING