Epidemiological mechanisms of genetic resistance to kuru.

  title={Epidemiological mechanisms of genetic resistance to kuru.},
  author={Katherine E Atkins and Jeffrey P. Townsend and Jan Medlock and Alison P. Galvani},
  journal={Journal of the Royal Society, Interface},
  volume={10 85},
Transmissible spongiform encephalopathies (TSEs), such as kuru, are invariably fatal neurodegenerative conditions caused by a malformation of the prion protein. Heterozygosity of codon 129 of the prion protein gene has been associated with increased host resistance to TSEs, although the mechanism by which this resistance is achieved has not been determined… CONTINUE READING