Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane.

@article{Ilyasova2004EpidemiologicalMF,
  title={Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane.},
  author={Dora Il'yasova and Jason D. Morrow and Anastasia Ivanova and Lynne E. Wagenknecht},
  journal={Annals of epidemiology},
  year={2004},
  volume={14 10},
  pages={
          793-7
        }
}
PURPOSE A biomarker of oxidant status applicable to epidemiological research is essential to studying the relationship between free radicals and chronic disease risk. Gas chromatography with mass-spectrometry detection (GC/MS) is the gold standard for measurement of urinary F2-isoprostanes (F2-isoPs), a non-invasive marker of oxidant status. However, this method is laborious and costly, which prohibits its use in large epidemiological studies. METHODS We compared GC/MS assay with an… CONTINUE READING

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The isoprostanes--25 years later.