Epidemiological evidence that physical activity is not a risk factor for ALS

  title={Epidemiological evidence that physical activity is not a risk factor for ALS},
  author={Bello Hamidou and Philippe Couratier and Cyril Besançon and Marie Nicol and Pierre-Marie Preux and Ben{\^o}it Marin},
  journal={European Journal of Epidemiology},
To elucidate whether physical activity (PA) and sport increase the risk of developing amyotrophic lateral sclerosis (ALS), a literature review of epidemiological studies was conducted according to the Meta-analysis of Observational Studies in Epidemiology guidelines. Six databases (Pubmed, Scopus, ScienceDirect, IngentaConnect, Refdoc and the Cochrane database) were searched to April 2014. Experts were asked to identify studies in press. Studies of interest were examined for their level of… 

Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis

There is a possibility that such a head-injury-oriented risk of ALS has been somewhat overestimated and it would be necessary to conduct more epidemiological studies that consider the time lags between the occurrence of head injuries and the diagnosis of ALS.

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

This is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire and large-scale prospective studies in the future may help to confirm this association.

Is there a link between physical activity and Amyotrophic Lateral Sclerosis

A recent literature review found that football/soccer may be considered as a possible risk factor for ALS (level C) and there is a strong need for further research that must take into account the numerous confounding factors that could be present in this field.

Life Course of Physical Activity and Risk and Prognosis of Amyotrophic Lateral Sclerosis in a German ALS Registry

A strong nonlinear association of current and prediagnostic PA level and survival in ALS cases with the best survival with moderate PA is found, suggesting PA intensity may be a disease-modifying factor with an unfavorable outcome in sedentary and hyperactive behavior.

IS THERE A LINK BETWEEN PHYSICAL ACTIVITY AND AMYOTROPHIC LATERAL SCLEROSIS ? Is there a link between physical activity and Amyotrophic Lateral Sclerosis ?

The Amyotrophic Lateral Sclerosis (ALS) is a chronic and progressive neuro-degenerative pathology that starts in adult age and usually leads patients to death for respiratory distress after 3 years

Physical activity in patients with amyotrophic lateral sclerosis: Prevalence, patients' perspectives and relation to the motor performance.

The majority of ALS patients perform regular PA and find it positively influence their motor performance and mood, and Bulbar disease onset, but not functional status, is a negative prognostic factor for regular exercise in ALS patients.

Environmental Risk Factors and Amyotrophic Lateral Sclerosis: An Umbrella Review and Critical Assessment of Current Evidence from Systematic Reviews and Meta-Analyses of Observational Studies

A small number of published meta-analyses on environmental factors and risk of ALS was identified, a phenomenon that could be attributed to the challenges in studying a rare neurological disease.

Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood

A prospective cohort study of young Swedish men who enlisted 1968–2005 and took part in comprehensive conscription examinations provides novel epidemiologic evidence of a prospective association between low overall muscle strength and erythrocyte volume fraction in young men and ALS risk.



Lifetime physical activity and the risk of amyotrophic lateral sclerosis

An increased risk of ALS with higher levels of leisure time physical activity was found and the lack of association with occupational physical activity and the absence of a dose–response relationship strengthen the hypothesis that not increased physical activity per se but rather a genetic profile or lifestyle promoting physical fitness increases ALS susceptibility.

An Evidence-Based Medicine Approach to the Evaluation of the Role of Exogenous Risk Factors in Sporadic Amyotrophic Lateral Sclerosis

Evidence supported the conclusion that the following were probably not risk factors for ALS: trauma, physical activity, residence in rural areas and alcohol consumption, and evidence in support of smoking being a probable (‘more likely than not’) risk factor for ALS.

Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan.

Sports and trauma in amyotrophic lateral sclerosis revisited

  • C. Armon
  • Medicine
    Journal of the Neurological Sciences
  • 2007

Prospective study of occupation and amyotrophic lateral sclerosis mortality.

Results, which suggest that male programmers and laboratory technicians and female machine assemblers may be at increased risk of death from ALS, should be interpreted cautiously, however, because they are based on small numbers.

Physical activity and the association with sporadic ALS

This study is the third to report a positive association between military service and incidence or death rates of ALS, and its main contribution is the finding that this association is not unique to Gulf War veterans.

Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study

Those without a record of CHD were at modestly higher risk of ALS, but not for PD or MS, which lends support to the assertion that ALS arises within a population who may have relatively higher levels of cardiovascular fitness.

Workplace Exposures and the Risk of Amyotrophic Lateral Sclerosis

The data suggest that certain occupations and workplace exposures may be associated with increased risk of ALS and need to be confirmed in independent populations.

Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence

  • Ceryl A HarwoodC. McdermottP. Shaw
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
The existing literature regarding physical activity as a risk factor for MND and the potential biological and genetic plausibility for this association are reviewed.

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

  • E. BeghiG. Logroscino B. Traynor
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2010
It is concluded that ALS is associated with physical exercise but not with traumatic events, compared to the general population.