Epidemiological burden of invasive pneumococcal disease in children and adolescents with predisposing risk factors.


OBJECTIVE Some medical conditions constitute important risk factors for the development of invasive pneumococcal diseases in children and adolescents aged from 5 to 19 years. Conjugate vaccines have potential efficacy in this scenario, but are not available in many Latin American public healthcare systems for this age group. This study aimed to estimate the preventable fraction of invasive pneumococcal diseases among individuals aged from 5 to 19 years with associated risk factors for its development. METHODS Data regarding the Latin America population, risk factors prevalence and conjugate vaccines efficacy were obtained from the literature. RESULTS Total population at risk ranged from 17.3 to 64.6 million of individuals and asthma was the most impacting risk factor. According to SIREVA, PCV13 provided a 62.9% serotypes coverage in individuals from 5 to 29 years in 2012, potentially increasing the covered population from [8,338,457-31,057,620] with PCV10 to [10,906,356-40,622,078] with PCV13. To date, according to available efficacy data, the hypothetically immunized population ranged from 11.4 to 42.4 million, representing 7.0% to 26.0% of the total population in this age group. CONCLUSIONS Vaccination in risk groups should be encouraged, as it potentially contributes to the reduction in the number of cases of invasive pneumococcal disease.

DOI: 10.1016/j.ijid.2015.06.016

Cite this paper

@article{FalleirosArlant2015EpidemiologicalBO, title={Epidemiological burden of invasive pneumococcal disease in children and adolescents with predisposing risk factors.}, author={Luiza Helena Falleiros-Arlant and Eitan Namaan Berezin and Maria Luisa Avila-Aguero and Mar{\'i}a Catalina P{\'i}rez and Angela M Gentile and Vesta L Richardson and Jos{\'e} Brea and Cristina Mari{\~n}o}, journal={International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases}, year={2015}, volume={38}, pages={1-6} }