Epidemiologic patterns of wild-type hepatitis A virus determined by genetic variation.

  title={Epidemiologic patterns of wild-type hepatitis A virus determined by genetic variation.},
  author={Betty H. Robertson and Bhawna Khanna and Omana V Nainan and H. S. Margolis},
  journal={The Journal of infectious diseases},
  volume={163 2},
Hepatitis A virus (HAV) isolates from different parts of the world are a single serotype. However, genetic analysis of the VP1 genome region of published HAV sequences suggested that distinct genotypes of HAV could be defined based upon the geographic source of the original isolates. To circumvent the process of cell culture adaptation or animal passage, a 247-bp segment within the VP1 genome region of wild-type HAV was amplified by reverse transcription followed by polymerase chain reaction… CONTINUE READING


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