Epidemiologic evaluation of screening for risk factors: application to genetic screening.

@article{Khoury1985EpidemiologicEO,
  title={Epidemiologic evaluation of screening for risk factors: application to genetic screening.},
  author={Muin J. Khoury and C A Newill and Gary A. Chase},
  journal={American journal of public health},
  year={1985},
  volume={75 10},
  pages={1204-8}
}
To assess the usefulness of screening for risk factors, we derived arithmetic relationships between screening parameters (sensitivity, specificity, and positive predictive value PPV) and risk factor frequency, disease frequency and relative risk. We evaluated these relationships in the special case of genetic markers and disease susceptibility. It can be shown that even in the face of very large relative risks, sensitivity and positive predictive value are affected by the relative magnitude of… CONTINUE READING

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