Epidemiologic assessment of risks of adverse reactions associated with intermittent exposure.

@article{Feldmann1993EpidemiologicAO,
  title={Epidemiologic assessment of risks of adverse reactions associated with intermittent exposure.},
  author={Ulrich Feldmann},
  journal={Biometrics},
  year={1993},
  volume={49 2},
  pages={419-28}
}
Measures of risk of adverse reactions, such as the absolute risk, the relative risk, and the excess risk, are analyzed for individuals who are exposed occasionally for periods of varying duration. This type of exposure is of particular importance for the epidemiologic assessment of drug safety. A Poisson point process model that allows for the simultaneous consideration of concomitant factors is derived for the estimation of the hazard rates. The model can judge acute adverse reactions and is… CONTINUE READING

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