Epidemiologic Evidence of Relationships Between Reproductive and Child Health Outcomes and Environmental Chemical Contaminants

  title={Epidemiologic Evidence of Relationships Between Reproductive and Child Health Outcomes and Environmental Chemical Contaminants},
  author={DonaldT. Wigle and Tye Elaine Arbuckle and Michelle C. Turner and Annie B{\'e}rub{\'e} and Qiuying Yang and Shiliang Liu and Daniel Krewski},
  journal={Journal of Toxicology and Environmental Health, Part B},
  pages={373 - 517}
This review summarizes the level of epidemiologic evidence for relationships between prenatal and/or early life exposure to environmental chemical contaminants and fetal, child, and adult health. Discussion focuses on fetal loss, intrauterine growth restriction, preterm birth, birth defects, respiratory and other childhood diseases, neuropsychological deficits, premature or delayed sexual maturation, and certain adult cancers linked to fetal or childhood exposures. Environmental exposures… 

Environmental exposures and development

It is suggested that critical attention be given to maternal and paternal exposures and gene expression as they relate to the mode of action of the putative developmental toxicant both prior to and during pregnancy.

Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies

Although the published animal studies may have characterized potential neurodevelopmental outcomes using endpoints not required by guideline studies, the effects were generally observed at or above effect levels measured in repeated-dose toxicology studies submitted to the U.S. Environmental Protection Agency (EPA).

Environmental contaminants and child’s growth

Mounting evidence suggests that child’s growth may be associated with prenatal or postnatal exposures to environmental contaminants, and improving exposure assessment and studying the contaminants as mixtures should allow to gain knowledge about the environmental determinants of growth and obesity.

Non-cancer effects of chemical agents on children's health.

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Environmental Chemicals and Preterm Birth: Biological Mechanisms and the State of the Science

Examining windows of vulnerability, disaggregating preterm birth by phenotypes, and measuring biomarkers of mechanistic pathways in these epidemiologic studies can improve the ability to detect associations with exposure, provide additional evidence for causality in an observational setting, and identify opportunities for intervention.

Children's environmental health based on birth cohort studies of Asia.

Prenatal Exposure to Environmental Contaminants and Newborn Immune System Biomarkers

In this primarily urban Canadian population of pregnant women and their newborns, maternal blood or urine concentrations of persistent organic pollutants, pesticides, and metals were not associated with immunotoxic effects that manifest as increased odds of elevated levels of IgE, TSLP or IL-33.

Health Outcomes in Children Associated with Prenatal and Early-Life Exposures to Air Pollution: A Narrative Review

Evidence from January 2000 to January 2022 supports a role for prenatal and early-childhood air pollution exposures adversely affecting health outcomes during development, and future studies are needed to identify both detrimental air pollutants from the exposure mixture and critical exposure time periods.

[Impact of chemical and physical environmental factors on the course and outcome of pregnancy].

  • R. SlamaS. Cordier
  • Medicine
    Journal de gynecologie, obstetrique et biologie de la reproduction
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Environmental Hazards: Evidence for Effects on Child Health

This review summarizes knowledge of associations between child health and development outcomes and environmental exposures, including lead, methylmercury, polychlorinated biphenyls (PCBs), dioxins and related polyhalogenated aromatic hydrocarbons (PHAHs), certain pesticides, environmental tobacco smoke, aeroallergens, ambient air toxicants, and ETS.

Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence

The epidemiological evidence for specific pesticide classes, families, and active ingredients were examined and summarized and recommendations were made for how to improve future studies in order to address the current pitfalls and gaps in the studies in this area.

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  • L. Mazur
  • Medicine
    Current problems in pediatric and adolescent health care
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P ediatric environmental health is the diagnosis, treatment, and prevention of illness caused by preconception, prenatal, perinatal, and pediatric exposures to environmental hazards; and the creation

Pesticide exposures and fetal death: a review of the epidemiologic literature.

There is a clear need for epidemiologic research that focuses on specific pesticide products or chemical families, with improved exposure assessment, and the potential role of solvents in developmental toxicity associated with pesticide use by both males and females should also be considered.

Effects of environmental tobacco smoke on the respiratory health of children.

Prenatal and postnatal exposures have an important impact on children's respiratory health and these effects are preventable if pregnant women and children are protected from exposure to environmental tobacco smoke.

In utero pesticide exposure and childhood morbidity.

Weight of evidence for an association between adverse reproductive and developmental effects and exposure to disinfection by-products: a critical review.

The weight of evidence demonstrated that no association with DBP exposure exists for over a dozen outcomes including low and very low birth weight, preterm delivery, some specific congenital anomalies, and neonatal death.

The Association of Waterborne Chloroform with Intrauterine Growth Retardation

R residence in municipalities where chloroform concentrations were ≥10 μg/liter was associated with an increased risk for intrauterine growth retardation and the ascertainment and classification of exposures to trihalomethanes, including such issues as the imprecision of using aggregate municipal measures for classifying exposure at the level of the individual.

Effect of parents' occupational exposures on risk of stillbirth, preterm delivery, and small-for-gestational-age infants.

In spite of limitations in the exposure data, the size of the exposed populations, and possible confounding, the results in this study encourage further evaluation of the effects of maternal exposure to lead and possibly solvents, as well as paternal exposure in the textile industry and to x-rays and benzene.