Epidemiologic Correlates of Pyrazinamide-Resistant Mycobacterium tuberculosis in New York City.

@article{Verdugo2015EpidemiologicCO,
  title={Epidemiologic Correlates of Pyrazinamide-Resistant Mycobacterium tuberculosis in New York City.},
  author={Dawn Verdugo and Dorothy Fallows and Shama Desai Ahuja and Neil W Schluger and Barry Kreiswirth and Barun Mathema},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 10},
  pages={6140-50}
}
Pyrazinamide (PZA) has important sterilizing activity in tuberculosis (TB) chemotherapy. We describe trends, risk factors, and molecular epidemiology associated with PZA-resistant (PZA(r)) Mycobacterium tuberculosis in New York City (NYC). From 2001 to 2008, all incident culture-positive TB cases reported by the NYC Department of Health and Mental Hygiene (DOHMH) were genotyped by IS6110-based restriction fragment length polymorphism and spoligotype. Multidrug-resistant (MDR) isolates underwent… CONTINUE READING
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