Epidemiologic Assessment of Worker Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) Concentrations and Medical Surveillance Examinations

  title={Epidemiologic Assessment of Worker Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) Concentrations and Medical Surveillance Examinations},
  author={Geary W. Olsen and Jean M. Burris and Michele M. Burlew and Jeffrey H. Mandel},
  journal={Journal of Occupational and Environmental Medicine},
Perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F) is used to create applications for surfactants and paper, packaging, and surface (eg, carpets, textiles) protectants. Such POSF-based products or their residuals may degrade or metabolize to PFOS (C8F17SO3−). PFOS concentrates in liver and serum and results in hypolipidemia as an early effect of cumulative dosages. Male and female employees of two perfluorooctanyl-manufacturing locations (Antwerp, Belgium and Decatur, Alabama) participated in a… 

Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy

The study revealed that human fetuses in Japan may be exposed to relatively high levels of FOCs, and found any significant correlations between PFOS concentration in maternal and cord blood samples and age bracket, birth weight, or levels of thyroid-stimulating hormone or free thyroxine.

Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.

In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry.

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

  • G. OlsenL. R. Zobel
  • Medicine
    International archives of occupational and environmental health
  • 2007
There was no evidence that employees’ serum PFOA concentrations were associated with total cholesterol or LDL, and several explanations are offered for the inconsistent triglyceride associations with PFO a including both methodological as well as biological possibilities.

Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant

This is the first large-scale report in children suggesting associations of serum PFOS and PFNA with thyroid hormone levels and of serum PFOA and hypothyroidism.

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Higher concentrations of serum PFOA and PFOS are associated with current thyroid disease in the U.S. general adult population and more work is needed to establish the mechanisms involved and to exclude confounding and pharmacokinetic explanations.

Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate-Contaminated Drinking Water

Regression analysis showed that age and male sex were significant predictors of PFOS, PFOA, and PFHxS; associations of other regressors (diet, body mass index) varied among PFCs.

Cord Serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at Birth

Despite relatively low cord serum concentrations, there are small negative associations between both PFOS and PFOA concentrations and birth weight and size and future studies should attempt to replicate these findings in other populations.



Serum perfluorooctane sulfonate and hepatic and lipid clinical chemistry tests in fluorochemical production employees.

The authors' analyses suggest that among these production employees, there were no substantial changes in serum hepatic enzymes, cholesterol, or lipoproteins associated with PFOS levels less than 6 ppm, and these results may be due to the lower levels of serum PFOS measured among theseproduction employees, compared to those suspected to cause effects in laboratory animals.

An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring.

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  • Chemistry
    AIHA journal : a journal for the science of occupational and environmental health and safety
  • 2003
This investigation randomly sampled a fluorochemical manufacturing employee population to determine the distribution of serum fluorochemical levels according to employees' jobs and work areas, and found the geometric means were approximately one order of magnitude higher than those observed for the film plant employees.

Mortality among employees of a perfluorooctanoic acid production plant.

  • F. GillilandJ. Mandel
  • Medicine, Biology
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1993
PFOA may increase prostate cancer mortality by altering reproductive hormones in male workers because of its reported role in rodent hepatocarcinogenesis and human health effects associated with PFOA exposure.


There is no significant clinical hepatic toxicity associated with PFOA levels as measured in male workers involved in ammonium perfluorooctanoate production, and unlike a previously reported observation, P FOA did not appear to modulate hepatic responses to either obesity or alcohol consumption.

An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid.

Results provide reasonable assurance that, in this production setting, there were no significant hormonal changes associated with PFOA at the serum levels measured, compared with those levels reported to cause effects in laboratory animal studies.

The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid.

Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.

There were no APFO-related macroscopic or microscopic changes, changes in clinical chemistry, hormones, or urinalysis, or hematological effects, and effects that have been associated with the development of pancreatic and testicular toxicity in rats were not observed in this study.

Structural determinants of fluorochemical-induced mitochondrial dysfunction.

  • A. StarkovK. Wallace
  • Biology, Chemistry
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2002
Data suggest that the protonated nitrogen atom with a favorable pKa is essential for the uncoupling action of perfluorooctane sulfonamides in mitochondria, which may be critical to the mechanism by which these compounds interfere with mitochondrial metabolism to induce peroxisome proliferation in vivo.