Epidemiologic Assessment of Worker Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) Concentrations and Medical Surveillance Examinations

@article{Olsen2003EpidemiologicAO,
  title={Epidemiologic Assessment of Worker Serum Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) Concentrations and Medical Surveillance Examinations},
  author={Geary W. Olsen and Jean M. Burris and Michele M. Burlew and Jeffrey H. Mandel},
  journal={Journal of Occupational and Environmental Medicine},
  year={2003},
  volume={45},
  pages={260-270}
}
Perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F) is used to create applications for surfactants and paper, packaging, and surface (eg, carpets, textiles) protectants. Such POSF-based products or their residuals may degrade or metabolize to PFOS (C8F17SO3−). PFOS concentrates in liver and serum and results in hypolipidemia as an early effect of cumulative dosages. Male and female employees of two perfluorooctanyl-manufacturing locations (Antwerp, Belgium and Decatur, Alabama) participated in a… 

Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy

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In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry.

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

  • G. OlsenL. R. Zobel
  • Medicine
    International archives of occupational and environmental health
  • 2007
There was no evidence that employees’ serum PFOA concentrations were associated with total cholesterol or LDL, and several explanations are offered for the inconsistent triglyceride associations with PFO a including both methodological as well as biological possibilities.

Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant

This is the first large-scale report in children suggesting associations of serum PFOS and PFNA with thyroid hormone levels and of serum PFOA and hypothyroidism.

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Higher concentrations of serum PFOA and PFOS are associated with current thyroid disease in the U.S. general adult population and more work is needed to establish the mechanisms involved and to exclude confounding and pharmacokinetic explanations.

Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate-Contaminated Drinking Water

Regression analysis showed that age and male sex were significant predictors of PFOS, PFOA, and PFHxS; associations of other regressors (diet, body mass index) varied among PFCs.

Cord Serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at Birth

Despite relatively low cord serum concentrations, there are small negative associations between both PFOS and PFOA concentrations and birth weight and size and future studies should attempt to replicate these findings in other populations.
...

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