Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals.

@article{Johnson1999EpidemicsOD,
  title={Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals.},
  author={Sonja E. Johnson and Matthew H. Samore and Kylie A Farrow and George E. Killgore and Fred C. Tenover and Dena Lyras and Julian I Rood and P C Degirolami and Aldona L Baltch and Mary Ellen Rafferty and S M Pear and Dale N. Gerding},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 22},
  pages={1645-51}
}
BACKGROUND Large outbreaks of diarrhea caused by a newly recognized strain of Clostridium difficile occurred in four hospitals located in different parts of the United States between 1989 and 1992. Since frequent use of clindamycin was associated with the outbreak in one of the hospitals, we examined the resistance genes of the epidemic-strain isolates and studied the role of clindamycin use in these outbreaks. METHODS Case-control studies were performed at three of the four hospitals to… CONTINUE READING

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