Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients

@article{Jrgensen2003EpidemicSO,
  title={Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients},
  author={I. M. J{\o}rgensen and H. Johansen and B. Frederiksen and T. Pressler and A. Hansen and P. Vandamme and N. H{\o}iby and C. Koch},
  journal={Pediatric Pulmonology},
  year={2003},
  volume={36}
}
We show that Pandoraea apista must be added to the increasing list of pathogens capable of causing chronic lung infection in cystic fibrosis (CF) patients. It is most likely that this strain of P. apista was transmissible among patients with CF, leading to spread of infection from the index patient to 5 other patients exposed during participation in winter camps and/or hospitalization. All patients developed chronic infection with high levels of antibodies, and 4 patients had a downhill course… Expand
Chronic Colonization with Pandoraea apista in Cystic Fibrosis Patients Determined by Repetitive-Element-Sequence PCR
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All strains of P. apista from patient I were identical, as were all strains from patient II, establishing chronic colonization and implying that the organism was not transferred from one patient to the other, suggesting the choice of methodology could generate misleading results when examining person-to-person transmission regarding this organism. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells.
TLDR
Only three isolates showed an ability to invade A549 lung epithelial cells, and only one isolate was able to form biofilms in vitro, suggesting pro-inflammatory response is likely to be a major factor in the pathogenesis of the genus. Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis
TLDR
It is suggested that guidelines to limit the acquisition of P cepacia should not be restricted to patients in hospital, and that intimate or frequent social contact is associated with a high risk of cross-infection. Expand
Pseudomonas aeruginosa and Burkholderia cepacia infection in cystic fibrosis patients treated in Toronto and Copenhagen
TLDR
It is suggested that the clinic populations had similar pulmonary and nutritional statuses despite differing clinic antibiotic treatment strategies, and early, aggressive anti‐pseudomonal chemotherapy may have reduced pseudomonal colonization among younger patients in Copenhagen. Expand
Cystic fibrosis. 1. Pseudomonas aeruginosa infection in cystic fibrosis and its management.
TLDR
Respiratory physicians will be concerned increasingly in the care of adult patients with cystic fibrosis and the management of their chronic lung infections, the most important of which is caused State Seruminstitute by Pseudomonas aeruginosa. Expand
Pandoraea apista isolated from a patient with cystic fibrosis: problems associated with laboratory identification
TLDR
A 17-year-old male patient with cystic fibrosis, with CF mutation homozygous ∆F508, was admitted to the Royal Belfast Hospital for Sick Children in August 2001 for a course of intravenous antibiotics to treat a chronic pulmonary infection and presently remains a part of the established resident bacterial flora. Expand
Fatal Pulmonary Infection Due to Multidrug-Resistant Mycobacterium abscessus in a Patient with Cystic Fibrosis
ABSTRACT We report a case of fatal pulmonary infection caused byMycobacterium abscessus in a young patient with cystic fibrosis, who underwent bipulmonary transplantation after a 1-year history ofExpand
Changing Epidemiology of Pseudomonas aeruginosa Infection in Danish Cystic Fibrosis Patients (1974–1995)
TLDR
Evaluating the impact of different modes of treatment and control of CF patients introduced at the Copenhagen CF Centre over the past 20 years on the changes in the epidemiology of PA found each to be associated with improved survival. Expand
Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
TLDR
Although some of the treated patients eventually developed chronic PA infection, these patients had significantly better pulmonary function at the onset of chronicPA infection compared with control patients, and there was a trend suggesting that 3 months of high‐dose treatment with colistin inhalation and oral ciprofloxacin produced the best results in terms of postponement or prevention. Expand
An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre.
TLDR
First-line use of older beta-lactam antibiotics, close bacteriological monitoring and prompt isolation of patients with resistant strains are recommended. Expand
Diagnosis and Treatment of Cystic Fibrosis
This review discusses some diagnostic aspects of cystic fibrosis (CF) including direct mutational analysis. Treatment of major disease manifestations is discussed in more detail with an emphasis onExpand
Mycobacterial lung disease in cystic fibrosis: a prospective study.
TLDR
Performing AFB smears and cultures in CF children with severe lung disease and/or during a lung exacerbation is recommended and persistence of M. chelonae or M. abscessus in sputum should lead to consideration of treatment with clarithromycin. Expand
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2
3
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