Epidemic meningococcemia and purpura fulminans with induced protein C deficiency.

  title={Epidemic meningococcemia and purpura fulminans with induced protein C deficiency.},
  author={Darleen R. Powars and Rune S. Larsen and Judy Johnson and T V Hulbert and Tong Sun and M J Patch and Rebecca L Francis and Louisa Chan},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={17 2},
Patients with epidemic infections caused by Neisseria meningitidis serogroup C were studied to assess the relationship of abnormal coagulation parameters to prognosis. Patients were categorized into stages within the first hour of observation according to severity of illness. During the epidemic years 1986 through 1991, 113 patients with bacteriologically proven N. meningitidis infection were observed, 15 of whom died. Purpura fulminans was seen in 28 patients, of whom 14 (50%) died. Among the… CONTINUE READING


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