Epidemic meningococcal disease: synthesis of a hypothetical immunoepidemiologic model.

@article{Griffiss1982EpidemicMD,
  title={Epidemic meningococcal disease: synthesis of a hypothetical immunoepidemiologic model.},
  author={John Mcleod Griffiss},
  journal={Reviews of infectious diseases},
  year={1982},
  volume={4 1},
  pages={159-72}
}
A hypothetical model of the epidermic behavior of Neisseria meningitidis, based upon the induction of susceptibility to disseminated disease by circulating IgA, is presented. The model is based on the assumption that epidemic susceptibility is acquired as a result of induction of serum IgA by cross-reacting enteric bacteria, the priming organism. Co-colonization with the appropriate strain of N. meningitidis then may result in disseminated disease. Colonization by either bacterium in the… CONTINUE READING

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