Epidemic meningitis, meningococcaemia, and Neisseria meningitidis

@article{Stephens2007EpidemicMM,
  title={Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
},
  author={David S. Stephens and Brian Greenwood and Petter Brandtzaeg},
  journal={The Lancet},
  year={2007},
  volume={369},
  pages={2196-2210}
}

Figures from this paper

Invasive Meningococcal Disease in the 21st Century—An Update for the Clinician

TLDR
This review covers key aspects of the pathogenesis and management of meningitis or bacteremia, as well as the very recent developments in disease epidemiology, outbreaks, and the evolution ofMeningococcal immunizations.

Neisseria meningitidis infection: who, when and where?

TLDR
Although a reduction in meningitis disease has been observed in Europe, a continuous surveillance is necessary to control any possible outbreaks of new hypervirulent clones into populations that could modify the epidemiology of meningococcal infections and the clinical spectrum of affected subjects.

Neisseria meningitidis B vaccines

TLDR
The aims of this article are to describe the most recent developments in meningitis B vaccines and to discuss how these vaccines can contribute to containing meningococcal disease.

Neisseria meningitidis: a silent killer?

TLDR
This review provides information about the morphology, cultivation, taxonomy, pathogenesis, clinical manifestations, laboratory diagnosis and therapy for Neisseria meningitidis.

Invasive Meningococcal Disease in the Vaccine Era

TLDR
This review summarizes clinical features of IMD and current treatment recommendations and will discuss the evidence for immunization and effects of vaccine strategies, particularly following implementation of effective vaccines against Group B meningococcus.

Impact of vaccination on meningococcal epidemiology

TLDR
Large-scale vaccination campaigns with the MCC vaccine and with MenAfriVac in the Sahel have clearly demonstrated the direct and indirect effect of immunization programmes on disease and carriage, and the introduction of novel subcapsular vaccines against serogroup B, which may cross-protect against other serogroups, is likely to have a further effect on trends.

Mechanisms of meningococcal colonisation.

Genetics and evolution of Neisseria meningitidis: importance for the epidemiology of meningococcal disease.

  • D. Caugant
  • Biology, Medicine
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2008

Meningococcal disease serogroup C

TLDR
A combination of all of the aforementioned approaches is useful in the prevention and control of MDC, and each country should tailor its public health policy to its own particular needs and knowledge of disease burden.
...

References

SHOWING 1-10 OF 208 REFERENCES

Epidemiology and pathogenesis of Neisseria meningitidis.

Update on meningococcal disease with emphasis on pathogenesis and clinical management.

TLDR
The overall mortality rate of meningococcal disease can only be reduced when patients without meningitis, i.e., those who may develop FMS, are recognized early, and the fundamental nature of the disease as aMeningococcus septicemia deserves more attention.

Serogroup B meningococcal vaccines.

TLDR
Progress toward an effective serogroup B vaccine, an important addition for meningococcal disease prevention, is the focus of this review.

Population genetics and molecular epidemiology of Neisseria meningitidis

  • D. Caugant
  • Medicine, Biology
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 1998
TLDR
The characteristics of the predominant clones which are nowadays causing meningococcal disease in the world are summarized here and the importance of population genetics in interpreting the epidemiological data is illustrated.

A universal vaccine for serogroup B meningococcus.

TLDR
The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity and has the potential to conquer one of the most devastating diseases of childhood.

Meningococcal meningitis in sub-Saharan Africa: a model for the epidemic process.

  • P. Moore
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1992
TLDR
Despite the unique behavior of group A meningococcal disease in sub-Saharan Africa, the application of similar methods of epidemiological analysis may be useful for determining epidemic processes for other diseases.

Manson Lecture. Meningococcal meningitis in Africa.

  • B. Greenwood
  • Medicine
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1999

Neisseria meningitidis: an overview of the carriage state.

TLDR
The high diversity of meningococcal carrier strains, compared with hypervirulent strains, supports the idea that transmissibility, not invasion, is essential in the life cycle of N. meningitidis.

Neisseria meningitidis strains isolated from invasive infections in France (1999-2002): phenotypes and antibiotic susceptibility patterns.

TLDR
In France, during 1999-2002, a total of 2167 clinical isolates of N. meningitidis from invasive infections were studied, and strains were heterogeneous and accounted for approximately 30% of isolates during this period, warranting continued surveillance of this phenomenon.
...