Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.

  title={Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.},
  author={Adam D. Kennedy and Michael Otto and Kevin R. Braughton and Adeline R. Whitney and Liang Chen and Barun Mathema and Jos{\'e} R. Mediavilla and Kelly Patrick Anthony Byrne and Larye Parkins and Fred C. Tenover and Barry Kreiswirth and James M. Musser and Frank R Deleo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 4},
Emerging and re-emerging infectious diseases, especially those caused by drug-resistant bacteria, are a major problem worldwide. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) appeared rapidly and unexpectedly in the United States, resulting in an epidemic caused primarily by isolates classified as USA300. The evolutionary and molecular underpinnings of this epidemic are poorly understood. Specifically, it is unclear whether there has been clonal emergence of USA300… CONTINUE READING


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