Epicatechin Reduces Spatial Memory Deficit Caused by Amyloid-β25–35 Toxicity Modifying the Heat Shock Proteins in the CA1 Region in the Hippocampus of Rats

@article{Daz2019EpicatechinRS,
  title={Epicatechin Reduces Spatial Memory Deficit Caused by Amyloid-$\beta$25–35 Toxicity Modifying the Heat Shock Proteins in the CA1 Region in the Hippocampus of Rats},
  author={Alfonso D{\'i}az and S. Trevi{\~n}o and Guadalupe Pulido-Fernandez and Estefan{\'i}a Mart{\'i}nez-Mu{\~n}oz and Nallely Cervantes and B. Espinosa and K. Rojas and F. P{\'e}rez-Severiano and S. Montes and M. Rubio-Osornio and Guevara Jorge},
  journal={Antioxidants},
  year={2019},
  volume={8}
}
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by dementia and the aggregation of the amyloid beta peptide (Aβ). Aβ25–35 is the most neurotoxic sequence, whose mechanism is associated with the neuronal death in the Cornu Ammonis 1 (CA1) region of the hippocampus (Hp) and cognitive damage. Likewise, there are mechanisms of neuronal survival regulated by heat shock proteins (HSPs). Studies indicate that pharmacological treatment with flavonoids reduces the prevalence of AD… Expand

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