Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery.

@article{Mewhort2016EpicardialIR,
  title={Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery.},
  author={Holly E. M. Mewhort and Jeannine D. Turnbull and Alessandro Satriano and Kelvin Chow and Jacqueline A. Flewitt and A Andrei and David G. Guzzardi and Daniyil A. Svystonyuk and James A. White and Paul W M Fedak},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2016},
  volume={35 5},
  pages={
          661-70
        }
}
BACKGROUND Infarcted myocardium can remodel after successful reperfusion, resulting in left ventricular dilation and heart failure. Epicardial infarct repair (EIR) using a bioinductive extracellular matrix (ECM) biomaterial is a novel surgical approach to promote endogenous myocardial repair and functional recovery after myocardial infarction. Using a pre-clinical porcine model of coronary ischemia-reperfusion, we assessed the effects of EIR on regional functional recovery, safety, and possible… CONTINUE READING