Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

  title={Epicardial FSTL1 reconstitution regenerates the adult mammalian heart},
  author={Ke Qiang Wei and Vahid Serpooshan and Cecilia Hurtado and Marta Diez-Cu{\~n}ado and Mingming Zhao and Sonomi Maruyama and WenHong Zhu and Giovanni Fajardo and Michela Noseda and Kazuto Nakamura and Xueying Tian and Qiaozhen Liu and Andrew Wang and Yuka Matsuura and Paul J. Bushway and Wenqing Cai and Alex Savchenko and Morteza Mahmoudi and Michael H. Schneider and Maurice J. B. van den Hoff and Manish J Butte and Phillip C Yang and Kenneth Walsh and Bin Zhou and Daniel Bernstein and Mark Mercola and Pilar Ruiz-Lozano},
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1… CONTINUE READING

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