Epibatidine application in vitro blocks retinal waves without silencing all retinal ganglion cell action potentials in developing retina of the mouse and ferret.

@article{Sun2008EpibatidineAI,
  title={Epibatidine application in vitro blocks retinal waves without silencing all retinal ganglion cell action potentials in developing retina of the mouse and ferret.},
  author={Chao Sun and Colenso M. Speer and Guo-yong Wang and Barbara Chapman and Leo M. Chalupa},
  journal={Journal of neurophysiology},
  year={2008},
  volume={100 6},
  pages={3253-63}
}
Epibatidine (EPI), a potent cholinergic agonist, disrupts acetylcholine-dependent spontaneous retinal activity. Early patch-clamp recordings in juvenile ferrets suggested that EPI blocks all retinal ganglion cell (RGC) action potentials when applied to the retina. In contrast, recent experiments on the developing mouse that relied on multielectrode array (MEA) recordings reported that EPI application decorrelates the activity of neighboring RGCs and eliminates retinal waves while preserving the… CONTINUE READING

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