Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges

  title={Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges},
  author={Roshan Rajan Kulkarni and Ah Reum Jo and Young Ho Kim and MinKyun Na},
− A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with… CONTINUE READING

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