Ephs and ephrins

@article{Taylor2017EphsAE,
  title={Ephs and ephrins},
  author={Hannah Taylor and Jessica Campbell and Catherine D. Nobes},
  journal={Current Biology},
  year={2017},
  volume={27},
  pages={R90-R95}
}
Eph receptors comprise the largest family of receptor tyrosine kinases (RTKs), with fourteen receptors divided into two subfamilies - EphAs and EphBs. Yet, despite their multitude of functions in almost all tissues of the body, these receptors represent one of the most underappreciated RTK families. What makes Eph receptors unique is that their cognate ligands, the ephrins, are tethered to the cell surface, in contrast to other RTKs whose ligands are generally soluble. This phenomenon means… CONTINUE READING
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