EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity

@inproceedings{Colbert2015EphrinB1NM,
  title={EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity},
  author={Paul L Colbert and Daniel W Vermeer and Bryant G. Wieking and John Hwa Lee and Paola D Vermeer},
  booktitle={Oncotarget},
  year={2015}
}
Microtubules (MTs) are components of the cytoskeleton made up of polymerized alpha and beta tubulin dimers. MT structure and function must be maintained throughout the cell cycle to ensure proper execution of mitosis and cellular homeostasis. The protein tyrosine phosphatase, PTPN13, localizes to distinct compartments during mitosis and cytokinesis. We have previously demonstrated that the HPV16 E6 oncoprotein binds PTPN13 and leads to its degradation. Thus, we speculated that HPV infection may… CONTINUE READING

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