Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.

@article{Gale2001EphrinB2SM,
  title={Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.},
  author={Nicholas Gale and Peter Baluk and Li Pan and Mildred Kwan and Jocelyn Holash and Tom M DeChiara and D M Mcdonald and George D. Yancopoulos},
  journal={Developmental biology},
  year={2001},
  volume={230 2},
  pages={
          151-60
        }
}
The Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands provide critical guidance cues at points of cell-to-cell contact. It has recently been reported that the ephrin-B2 ligand is a molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium. These findings suggested that ephrin-B2 and EphB4 are involved in establishing arterial versus venous identity and perhaps in… CONTINUE READING
Highly Cited
This paper has 150 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

Perfusable branching microvessel bed for vascularization of engineered tissues.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 16 Excerpts
Highly Influenced

Molecular distinction between arteries and veins

Cell and Tissue Research • 2003
View 7 Excerpts
Highly Influenced

151 Citations

01020'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 151 citations based on the available data.

See our FAQ for additional information.