Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.

@article{Gale2001EphrinB2SM,
  title={Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.},
  author={Nicholas Gale and Peter Baluk and Li Pan and Mildred Kwan and Jocelyn Holash and Tom M DeChiara and D M Mcdonald and George D. Yancopoulos},
  journal={Developmental biology},
  year={2001},
  volume={230 2},
  pages={
          151-60
        }
}

• Nicholas Gale, Peter Baluk, +5 authors George D. Yancopoulos
• Published 2001 in Developmental biology

The Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands provide critical guidance cues at points of cell-to-cell contact. It has recently been reported that the ephrin-B2 ligand is a molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium. These findings suggested that ephrin-B2 and EphB4 are involved in establishing arterial versus venous identity and perhaps in… CONTINUE READING

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