Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

  title={Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis},
  author={Suphansa Sawamiphak and Sascha Seidel and Clara Essmann and George Albert Wilkinson and Mara Elena Pitulescu and Till Acker and Amparo Acker-Palmer},
The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control the guidance of tip cells are poorly understood. Bidirectional signalling by Eph receptors and ephrin ligands represents one of the most important guidance cues involved in axon… CONTINUE READING
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