Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.

  title={Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus.},
  author={Matthew I Bonaparte and Antony S. Dimitrov and Katharine N. Bossart and Gary S Crameri and Bruce A. Mungall and Kimberly A Bishop and Vidita Choudhry and D. S. Dimitrov and Linfa Wang and Bryan T. Eaton and Christopher C. Broder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 30},
Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus of the family Paramyxoviridae and are unique in that they exhibit a broad species tropism and cause fatal disease in both animals and humans. They infect cells through a pH-independent membrane fusion process mediated by their fusion and attachment glycoproteins. Previously, we demonstrated identical cell fusion tropisms for HeV and NiV and the protease-sensitive nature of their unknown cell receptor and identified a human… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 113 extracted citations

Similar Papers

Loading similar papers…