Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature.

@article{Maekawa2003EphrinB2IM,
  title={Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature.},
  author={Hiromitsu Maekawa and Yuichi Oike and Shigeru Kanda and Yasuhiro Ito and Yoshihiro Yamada and Hiroki Kurihara and Ryozo Nagai and Toshio Suda},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 11},
  pages={2008-14}
}
OBJECTIVE Ephrin-B2 plays a key role in vascular development. The purpose of this study was to elucidate the molecular mechanisms of ephrin-B2 signaling through the EphB receptor in endothelial cells and to determine whether ephrin-B2 contributes to in vivo angiogenesis in adult mice. METHODS AND RESULTS A chemotaxis assay on a polycarbonate membrane revealed that ephrin-B2/Fc chimeric protein induced migration of human umbilical vein endothelial cells (HUVECs) at a level 98% greater than… CONTINUE READING