Ephrin-B1 is critical in T-cell development.

  title={Ephrin-B1 is critical in T-cell development.},
  author={Guang Sheng Yu and Jianning Mao and Yulian Wu and Hongyu Luo and Jiang-ping Wu},
  journal={The Journal of biological chemistry},
  volume={281 15},
Eph kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. In this study, we investigated the role of EFNB1 and the Ephs it interacts with (collectively called EFNB1 receptors) in mouse T-cell development. In the thymus, CD8 single positive (SP) and CD4CD8 double positive (DP) cells expressed high levels of EFNB1 and EFNB1 receptors, whereas CD4 SP cells had moderate expression of both. Soluble EFNB1-Fc in fetal thymus… CONTINUE READING