Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping

@article{Pfeiffenberger2005EphrinAsAN,
  title={Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping},
  author={Cory Pfeiffenberger and Tyler Cutforth and Georgia F Woods and Jena Yamada and Ren{\'e} C. Renter{\'i}a and David R. Copenhagen and John G. Flanagan and David A Feldheim},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1022-1027}
}
In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated… CONTINUE READING
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