Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner.

@article{Davy2000EphrinA5MC,
  title={Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner.},
  author={Alice Davy and Stephen M. Robbins},
  journal={The EMBO journal},
  year={2000},
  volume={19 20},
  pages={5396-405}
}
The ephrins are membrane-tethered ligands for the Eph receptor tyrosine kinases, which play important roles in patterning of the nervous and vascular systems. It is now clear that ephrins are more than just ligands and can also act as signalling-competent receptors, participating in bidirectional signalling. We have recently shown that ephrin-A5 signals within caveola-like domains of the plasma membrane upon engagement with its cognate Eph receptor, leading to increased adhesion of the cells to… CONTINUE READING

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