Ephaptic coupling of cortical neurons

@article{Anastassiou2011EphapticCO,
  title={Ephaptic coupling of cortical neurons},
  author={Costas A. Anastassiou and Rodrigo Perin and Henry Markram and Christof Koch},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={217-223}
}
The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potential across the neuronal membrane via ephaptic coupling, independent of synapses. The extent to which such ephaptic coupling alters the functioning of neurons under physiological conditions remains unclear. To address this question, we stimulated and recorded from rat cortical pyramidal neurons in slices… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions.
TLDR
Field effects and ion fluctuations probably have modest effects during physiological activity but have a significant impact on epileptic seizures, and can sustain them in the absence of synaptic transmission. Expand
Transcranial Electric Stimulation Entrains Cortical Neuronal Populations in Rats
TLDR
Intracellular recordings showed that both spiking and subthreshold activity were under the combined influence of TES forced fields and network activity, suggesting that TES in chronic preparations may be used for experimental and therapeutic control of brain activity. Expand
Synaptic Background Activity Influences Spatiotemporal Integration in Single Pyramidal Cells.
TLDR
The electrical behavior of an anatomically reconstructed layer V cortical pyramidal cell receiving input from 4000 excitatory and 1000 inhibitory cells firing spontaneously at 0-7 Hz significantly changes the response of the cell to temporal desynchronized versus temporal synchronized synaptic input distributed throughout the neuron. Expand
Electrical Interactions via the Extracellular Potential Near Cell Bodies
  • G. Holt, C. Koch
  • Medicine, Physics
  • Journal of Computational Neuroscience
  • 2004
TLDR
This work estimated the extracellular potentials associated with an action potential in a cortical pyramidal cell using standard one-dimensional cable theory and volume conductor theory and discusses their possible functional relevance. Expand
Field Effects in the CNS Play Functional Roles
TLDR
The principles of field effect interactions are described, identified field effects in diverse brain structures from the teleost Mauthner cell to the mammalian cortex are discussed, and the function of these interactions is speculated on. Expand
The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons
TLDR
It is shown through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing and imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity. Expand
Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
TLDR
It is shown that an internal brain state dynamically regulates cortical membrane potential synchrony during behaviour and defines different modes of cortical processing in behaving mice. Expand
Direct Activation of Sparse, Distributed Populations of Cortical Neurons by Electrical Microstimulation
TLDR
The results indicate that the pattern of activated neurons likely arises from the direct activation of axons in a volume tens of microns in diameter, and that microstimulation sparsely activates neurons around the electrode, sometimes as far as millimeters away, even at low currents. Expand
Theta oscillations in somata and dendrites of hippocampal pyramidal cells in vivo: Activity‐dependent phase‐precession of action potentials
TLDR
Data indicate that distal dendritic depolarization of the pyramidal cell by the entorhinal input during theta overlaps in time with somatic hyperpolarization, and hypothesize that the competition between the out‐of‐phase theta oscillation in the soma and dendrite is responsible for the advancement of spike discharges observed in the behaving animal. Expand
Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cells
TLDR
Observations suggest that dendritic currents underlying theta in the awake rat may not be revealed under urethane anesthesia, and cellular‐synaptic generation of rhythmic slow activity in the hippocampus is investigated by intracellular recording from principal cells and basket cells in anesthetized rats. Expand
...
1
2
3
4
5
...