EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer.

@article{Mao2004EphB2AA,
  title={EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer.},
  author={Weiguang Mao and E. Garza-Castanon Luis and Sarajane Ross and Johnny L. da Silva and Christine Tan and Craig W. Crowley and Clarissa Chui and Gretchen Franz and Peter D. Senter and Hartmut Koeppen and Paul Polakis},
  journal={Cancer research},
  year={2004},
  volume={64 3},
  pages={781-8}
}
Analysis of human colorectal cancer specimens revealed overexpression of the EphB2 receptor tyrosine kinase. Monoclonal antibodies (MAbs) to extracellular sequence of EphB2 were raised and tested for activity against colorectal cancer cells. One of the MAbs, 2H9, effectively blocked the interaction of ephB2 with ephrin ligands and inhibited the resulting autophosphorylation of the receptor. However, this antibody did not affect the proliferation of cancer cells expressing ephB2… CONTINUE READING

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