EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.

@article{Salvucci2006EphB2AE,
  title={EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.},
  author={Ombretta Salvucci and Maria de la Luz Sierra and Jos{\'e} A Martina and Peter J. McCormick and Giovanna Tosato},
  journal={Blood},
  year={2006},
  volume={108 9},
  pages={2914-22}
}
The complex molecular mechanisms that drive endothelial cell movement and the formation of new vessels are poorly understood and require further investigation. Eph receptor tyrosine kinases and their membrane-anchored ephrin ligands regulate cell movements mostly by cell-cell contact, whereas the G-protein-coupled receptor CXCR4 and its unique SDF-1 chemokine ligand regulate cell movement mostly through soluble gradients. By using biochemical and functional approaches, we investigated how… CONTINUE READING
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Defects Eph RECEPTORS REGULATE ENDOTHELIAL CELLS 2921 BLOOD, 1 NOVEMBER

  • T Nagasawa, S Hirota, K Tachibana
  • For personal use only. on July 15,
  • 2006

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