EphB2 activation is required for ependymoma development as well as inhibits differentiation and promotes proliferation of the transformed cell

@inproceedings{Chen2015EphB2AI,
  title={EphB2 activation is required for ependymoma development as well as inhibits differentiation and promotes proliferation of the transformed cell},
  author={Phylip Chen and Nathan Rossi and Samuel Priddy and Christopher R. Pierson and Adam W. Studebaker and Robert A. Johnson},
  booktitle={Scientific reports},
  year={2015}
}
Our intracranial implantation mouse model of ependymoma clearly demonstrates overexpression of the ephrin receptor EphB2 in Ink4a/Arf((-/-)) supratentorial embryonic neural stem cells (STeNSCs) to be essential for transformation and disease development; however the requirement for and consequence of receptor activation on transformation and neural stem cell… CONTINUE READING