EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.

  title={EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.},
  author={C{\'e}cile Vindis and Thalia Teli and Douglas Pat Cerretti and C. Heath Turner and Uyen Huynh-Do},
  journal={The Journal of biological chemistry},
  volume={279 27},
Interactions between Eph receptors and their membrane-bound ligands (ephrins) are of critical importance for key developmental processes such as boundary formation or vascular development. Their downstream signaling pathways are intricate and heterogeneous at several levels, the combined effect being a highly complex and flexible system. Here we demonstrate that activated EphB1 induces tyrosine phosphorylation of the focal adhesion protein paxillin at Tyr-31 and Tyr-118 and is recruited to… CONTINUE READING

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